Absorption of Nicotine from E-Cigarette Usage: Comparing first and new generation gadgets

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Absorption of Nicotine from E-Cigarette Usage: Comparing first and new generation gadgetsA new study carried today in “Nature: Scientific Reports” journal reports that along with his team, Dr. Farsalino evaluated potential for nicotine absorption by diverse kinds of e-cigarette gadgets. A 1st-generation device resembling a cigarette that used a cartomizer got compared with new-generation gadget with a power rating of 9 watts using a clearomizer. An e-liquid of 18mg/ml containing nicotine was utilised within the study and was identical for both gadgets. A group of seasoned vapers got recruited. The participants employed both gadgets for one hour, in cross-over design of randomised nature on two different days, following an 8-hour abstinence from use of e-cigarettes. They were permitted to utilise the much e-liquid they required, as well as new cartomizers and batteries if necessary for the 1-hour duration.

Results of the study indicated that absorption of nicotine from electronic cigarettes was lowered significantly in comparison to cigarettes with tobacco. In real sense, 5 usage minutes occasioned plasma nicotine concentrations of between 1/3rd and 1/4th, relative to smoking one tobacco cigarette. Greater efficiency in delivery of nicotine came with the new-generation gadget, with levels of nicotine being higher by 35-72 percent, compared to those observed when using the 1st-generation device. After an hour’s use in fact, users were unable to obtain levels of plasma nicotine similar to those of smoking a single cigarette within 5 minutes. These results indicate that absorption of nicotine from electronic cigarettes is fairly slow and possibly resembles that observed with NRTs. Our conclusion was that a 50mg/ml minimum would be required to facilitate nicotine absorption approximately equal to that obtained from regular smoking.

The outcome would cause the electronic cigarette a more effective option for smokers (particularly heavy ones) and might occasion lower liquid consumption (as it would reduce need for continuously using the e-cigarette for long periods of time).

The study adds to evidence which shows the 20mg/ml limit of nicotine proposed by the EU is not appropriate and could result in negative impact on public health, as it will deprive many smokers opportunity of switching successfully from tobacco to e-cigarettes.

The survey is on offer for free along with full text access here

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